NAD+ Nicotinamide Adenine Dinucleotide Vial For Lab Research

BATCH NR: NBLNJ10007261101

TESTED FOR:

✓PURITY (HPLC)
✓WEIGHT
✓ENDOTOXINS(LPS)

VIEW LAB REPORTS

Overview

NAD+ is a fundamental coenzyme present in all living cells, playing a central role in cellular energy metabolism and redox reactions.

It functions primarily as an electron carrier in metabolic pathways, enabling the conversion of nutrients into cellular energy (ATP). In research contexts, NAD+ is also widely studied in relation to aging biology, mitochondrial function, and DNA repair mechanisms.

NAD+ levels are known to decline with age in multiple model organisms, which has led to extensive investigation of its role in age-associated metabolic and cellular changes.

Mechanism of Action

NAD+ operates through several core biological pathways:

1. Redox Reactions (Energy Metabolism)

✓ Acts as a coenzyme in oxidation-reduction reactions
✓ Cycles between NAD+ (oxidized) and NADH (reduced) forms
✓ Essential for glycolysis, TCA cycle, and oxidative phosphorylation
✓ Supports ATP production in mitochondria

2. Sirtuin Activation Pathways

✓ Serves as a required substrate for sirtuin enzymes (SIRT1–SIRT7)
✓ Influences gene expression related to stress resistance and metabolism
✓ Modulates cellular repair and survival pathways (research models)

3. DNA Repair and Genomic Stability

✓ Consumed by PARP enzymes during DNA damage response
✓ Supports cellular repair mechanisms under oxidative stress
✓ Linked to maintenance of genomic integrity in experimental models

4. Mitochondrial Function

✓ Regulates mitochondrial biogenesis indirectly via signaling pathways
✓ Influences respiratory chain efficiency
✓ Associated with cellular energy homeostasis in research studies

Research Applications

NAD+ is studied across multiple scientific domains:

Metabolic Research

• Energy metabolism regulation

• Mitochondrial respiration efficiency

• Glucose and lipid metabolism pathways

Aging and Longevity Research

• Age-related NAD+ decline models

• Cellular senescence studies

• Sirtuin-mediated longevity pathways

• Oxidative stress response mechanisms

Neurobiology Research

• Neurodegeneration models (Alzheimer’s, Parkinson’s pathways)

• Neuronal energy metabolism

• Synaptic plasticity and repair mechanisms

DNA Repair and Genomic Research

• PARP enzyme activity studies

• DNA damage response pathways

• Cellular stress adaptation

Exercise Physiology (Experimental Models)

• Muscle mitochondrial efficiency

• Endurance metabolism pathways

• Recovery and cellular stress response

Technical Specifications

Stability & Storage

Solid / Powder Form

• Store at -20°C or below

• Protect from light exposure

• Minimize moisture contact

• Avoid repeated freeze-thaw cycles

Solution Form

• Store at 2–8°C (short-term)

• Rapid degradation possible in aqueous environments

• Stability depends heavily on pH and buffer composition

• Best used freshly prepared in experimental settings

Pharmacokinetic / Biological Notes (Research Data)

Unlike peptides or drugs, NAD+ is:

• Rapidly metabolized within cells

• Continuously recycled between NAD+ and NADH pools

• Not stable as a circulating long-lived molecule in vivo

• Synthesized via salvage and de novo pathways

Key Pathways of Synthesis

✓ Salvage pathway (nicotinamide recycling)
✓ Preiss–Handler pathway (niacin-derived)
✓ Tryptophan conversion pathway (de novo synthesis)

Research Keywords / PubMed Search Terms

Researchers commonly use:

Core NAD+ Topics

• NAD+ metabolism

• nicotinamide adenine dinucleotide redox

• cellular NAD+ levels aging

• mitochondrial NAD+ function

Aging Research

• NAD+ decline aging model

• sirtuin activation NAD+

• longevity metabolic pathways

• cellular senescence NAD+

Neurobiology

• NAD+ neuroprotection

• mitochondrial dysfunction neurons NAD+

• neurodegenerative disease metabolism

Research Use Only Disclaimer

FOR RESEARCH USE ONLY

This material is intended exclusively for laboratory research by qualified professionals.

This substance:

• Is not approved for human use as a drug in this context

• Is not intended to diagnose, treat, cure, or prevent any disease

• Is not a dietary supplement in this format

• Must only be used in controlled laboratory or research environments

All descriptions reflect current scientific literature and experimental models. Biological effects observed in model systems may not directly translate to human outcomes.

Scientific References

1. Covarrubias AJ, Perrone R, Grozio A, Verdin E.
NAD+ metabolism and its roles in cellular processes.
Nature Reviews Molecular Cell Biology. 2021.

2. Rajman L, Chwalek K, Sinclair DA.
Therapeutic potential of NAD-boosting molecules.
Nature Reviews Drug Discovery. 2018.

3. Verdin E.
NAD+ in aging, metabolism and neurodegeneration.
Science.