AOD9604 Peptide Vial Lyophilisate For Lab Research

BATCH NR: NBL5AD07261101

TESTED FOR:

✓PURITY
✓WEIGHT
✓ENDOTOXINS(LPS)

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Overview

AOD-9604 is a synthetic peptide derived from the C-terminal region of human growth hormone (hGH), corresponding to amino acids 176–191. It was developed to isolate metabolic properties of growth hormone independent of growth-promoting activity. In research settings it is primarily investigated for lipid metabolism, adipose tissue regulation, and energy homeostasis. Unlike native hGH, AOD-9604 has not been shown in the literature to significantly stimulate IGF-1 production, which researchers have used to study metabolic pathways independently of broader endocrine signaling.

Mechanism of Action (as reported in preclinical literature)

• Promotion of lipolysis (fat breakdown) in experimental models
• Inhibition of lipogenesis
• Modulation of adipocyte signaling pathways
• Potential involvement of β3-adrenergic receptor-associated mechanisms
• Increased fatty acid mobilization observed in experimental models

Unlike full-length hGH, AOD-9604 appears in preclinical studies to act without significant activation of the growth hormone receptor pathway or substantial increases in circulating IGF-1.

Proposed mechanisms are based on experimental and preclinical research; human physiological outcomes remain under investigation.

Research Applications

• Metabolic Research: energy homeostasis, nutrient utilization, metabolic pathway regulation
• Adipose Tissue Biology: fat cell function, lipid storage dynamics, adipocyte signaling
• Lipolysis Research: triglyceride breakdown, fat oxidation pathways, energy expenditure
• Obesity & Body Composition Models: experimental weight-management research, fat distribution, metabolic syndrome
• Comparative GH-Fragment Research: selective hGH fragment activity, endocrine-independent metabolic effects

Technical Specifications

Stability & Storage

Lyophilized: Store at -20°C; protect from light/moisture; avoid repeated freeze-thaw. Reconstituted: Store at 2–8°C; use per laboratory handling protocols; maintain sterile conditions.

AOD-9604 is susceptible to enzymatic degradation — proper storage/handling is essential to preserve integrity throughout the research process.

Pharmacokinetic Notes (Research Data)

Reported half-life approximately 20–30 minutes in experimental pharmacokinetic studies; rapid systemic clearance typical of small peptide compounds.

Research Use Only — Please Read

FOR RESEARCH USE ONLY. This product is intended exclusively for laboratory research by qualified professionals.

This product:

• Is not approved for human use
• Is not approved for veterinary use
• Is not intended to diagnose, treat, cure, or prevent any disease
• Is not a dietary supplement
• Must not be used in clinical applications

The information provided is for educational and research purposes only and reflects findings from published scientific literature. Experimental results obtained in vitro or in animal models may not predict outcomes in humans.

Scientific References

1. Heffernan M, Summers RJ, Thorburn A, et al.
The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice.
Endocrinology. 2001.

2. Stier H, Vos E, Kenley D.
Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans.
Journal of Endocrinology and Metabolism. 2013.

3. Cox HD, Smeal SJ, Hughes CM, et al.
Detection and in vitro metabolism of AOD9604.
Drug Testing and Analysis. 2015.