Information about the product Ibutamoren (MK-677)
Ibutamoren, also known as MK-677, is a prominent anabolic research molecule among scientists, particularly in animal studies because of its intriguing ability to efficiently enhance lean body mass with the goal of developing muscle. The research focus has changed from determining whether it can raise growth hormone levels to determine whether MK-677 supplementation can increase muscle mass, muscle strength, and body fat levels.
The production of IGF 1 in the liver and activating the pituitary gland to produce more growth hormones are two mechanisms by which MK-677 chemicals may promote the creation of new muscle cells. Studies suggest that the combination of these hormones may improve nitrogen retention, speed up recovery, and increase protein synthesis and strength.
24 obese mice were treated with MK-677 treatment for two months in a double-blind randomized controlled experiment. Their basal metabolic rates and muscle mass both increased, according to the results. In a different mouse study, it was discovered that MK-677 has the ability to stop muscle loss and atrophy. Another investigation with mice with broken hips discovered evidence of stronger muscles after giving an MK-677 research cycle.
Ibutamoren MK 677 CAS Number 159634-47-6
Chemical Formula: C14H12F6N2O
Molar Mass: 528.67 g
Molar Name: IUPAC2-aminoN-[1-(1-methylsulfonylspiro[2H indole-3,4-piperidine]-1′-yl]-2-methyl]-1-oxo-3-phenylmethoxypropan-2-yl]propenamide
How Does MK 677 Function?
According to research conducted on animals, MK 677 acts similarly to ghrelin, the growth hormone (GH) secretagogue that promotes GH secretion. In order to increase GH levels, MK 677 binds to and activates a ghrelin receptor (GHSR) in the brain.
The potential to increase GH levels with MK 677 has been supported by numerous research. Ibutamoren raises GH following oral doses as low as 0.125 mg/kg, according to one study on dogs. Another experiment on animals revealed that chronic MK-677 administration raised peak GH levels. [R] [R]
The same conclusion was found in three double-blind, placebo-controlled clinical investigations. For two to nine weeks, subjects received bodyweight-dependent dosages of MK 677. When compared to samples taken at the start of the trial, the end findings revealed a consistent rise in GH levels. [R]
SARMs and MK-677
MK 677, a growth hormone secretagogue, is frequently categorized with SARMs or selective androgen receptor modulators. This is primarily due to the fact that it has generated results that are somewhat similar in animal, pre-clinical, and clinical investigations.
MK 677 is not a SARM, despite having similar properties. Selected androgen receptor modulators function by attaching to androgen receptors, which are mostly found in bone and muscle tissue. As previously mentioned, butamoren has the ability to replicate ghrelin’s effects on the brain.
Ibutamoren belongs to the family of peptides that release growth hormone when effects are taken into account. MK 677 binds to the ghrelin/growth hormone secretagogue receptor to promote the release of GH, just like Hexarelin, GHRP-2, and GHRP-6.
The fact that Ibutamoren is not a SARM may be advantageous. SARMs have the potential to affect testosterone production naturally and decrease it. As a result, while giving SARMs to research participants, researchers must exercise extreme caution. MK 677 doesn’t require the same safety measures.
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MK-677 Ibutamoren Research
Multiple animal studies have been conducted using MK-677. This GH-secretagogue has also attracted various clinical trials. In this section, we’re going to take a comprehensive look at what these studies have found about Ibutamoren.
MK-677 and Growth Hormone
A study was conducted to determine the effect of MK-677 on growth hormone release in obese subjects. The study involved oral treatment of MK-677 and recruited twenty-four healthy obese subjects. The impact of oral administration of MK 677 on GH secretion was observed.
The final results showed that there was a significant increase in GH levels. Another encouraging sign was that the increase persisted at 2 and 8 weeks of treatment. It was also observed that the initial dose of MK-677 produced a greater increase in GH levels than any of the upcoming doses. [R]
MK-677 and IGF-1
Insulin-like growth factor 1 is a hormone that plays many crucial functions in the human body. These include fetal development, childhood growth, and anabolic effects in adults. Aside from that, IGF-1 has also been proven to help with muscle regeneration and offer neural protective effects. [R]
A double-blind study has shown that MK-677 could potentially increase IGF-1 levels in patients with mild to moderate Alzheimer’s disease. A 60.1% increase was observed 6 weeks after the beginning of MK-677 treatment. The rate of increase reached 72.9% at 12 months. [R]
MK-677 and Body Composition
In a 24-month-long placebo-controlled trial, Ibutamoren administration led to increased GH and IGF-1 levels with no severe side effects in research subjects. Researchers demonstrated that this resulted in a potential increase in body weight, a decrease in LDL (“bad”) cholesterol levels, and an increase in bone density. [R]
Similar results were obtained following a two-month treatment of obese subjects with MK-677. Fat-free mass saw a significant increase in the Ibutamoren treatment group, compared to the placebo group. However, no effect on body fat was observed. [R]
MK-677 and Bone Density
There is a direct relationship between GH levels in the body and bone mineral density. Various studies show that an increase in GH leads to stronger bones. That explains why older adults, who have lower GH levels than their younger counterparts, tend to have weaker bones. [R]
Research involving elderly adults found that MK-677 has the potential to stimulate bone turnover and increase bone deposition and formation. This could positively impact bone density, as highlighted by another study in which MK-677 treatment improved gait speed and reduced the number of falls in elderly patients with hip fractures. However, more research is needed. [R] [R]
MK-677 and Sleep Quality
Sleep is one of the most essential body functions. Research has shown that a good night’s sleep can boost learning, decision-making, memory, and creativity. What’s more, short sleep duration and poor sleep quality are linked to mass muscle reduction. [R]
To determine the impact of MK-677 on sleep quality, one study group was administered this GH secretagogue while the other was given a placebo. Results showed that the MK-677 group had a 20% increase in REM sleep and a 50% increase in the duration of stage IV compared to the placebo group. [R]
Where to Buy MK677 for Research Purposes?
Nord Bio Lab provides high-quality, research-grade products. The MK-677 for sale comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration. Our great customer service and fast shipping help us stand out from the competition.
What Is The Half-Life of MK 677?
Animal research indicates that MK-677 has an elimination half-life of 4-6 hours.
What Are The Potential Side Effects of MK-677?
A two-year clinical study indicates that the most frequent side effects of MK-677 on research subjects tend to be mild. These include increased appetite, transient muscle pain, and lower-extremity edema. Researchers conducting the study noted that most side effects subsided in a few months.
MK677 or Ibutamoren is a growth hormone secretagogue. Research conducted on animals as well as multiple clinical studies has shown that it has the potential to increase levels of GH and IGF-1.
Aside from that, several clinical trials have shown that this research chemical is generally safe. However, it is yet to be approved for human consumption and can only be acquired for laboratory research use.
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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Product intended for research purposes
- The product (substance) isn’t a food or diet supplement and is unsuitable for human consumption.
- Keep out of children’s reach.
- Keep the container tightly closed.
- Store in a dry, cool and shaded place; protect from moisture.
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The substance is not a food product or dietary supplement, it is not suitable for human consumption. The product is classified as a chemical reagent approved for trading in the European Union, it can only be used for scientific research.