Testolone RAD 140 – Product Information
A non-steroidal selective androgen receptor modulator (SARM), RAD-140 is also known as Testolone. It is being investigated for its propensity to bind to particular androgen receptors, like other SARMs, and as a result does not have the same range of androgenic side effects as drugs like anabolic steroids, DHT, or testosterone replacement therapy.
There hasn’t been testosterone for very long. In reality, this research substance was created in 2010 as a potential osteoporosis therapy. It is primarily being researched at the time of writing as a research substance with the potential to boost muscle growth and encourage muscular improvements.
According to studies, RAD-140 is highly stable when incubated with rat, monkey, and human microsomes. The research substance also showed strong affinity for the androgen receptor in skeletal tissue and good bioavailability in rats and monkeys.
Recent research looked at how RAD-140 affected the size of the prostate and the levator ani muscles in castrated rats, which are sensitive indicators of the anabolic-androgenic activity in juvenile nonhuman primates. According to the final findings, RAD-140 stimulates the levator ani muscle.
CAS Number: 1182367-47-0
Chemical Formula: C20H16ClN5O2
IUPAC Name: 2-chloro-4-[(1R,2S)] Molar Mass 393.83 g/mol-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino}-3-methylbenzonitrile
On RAD-140, numerous animal investigations have been carried out. Additionally, this research substance has been the subject of numerous clinical tests or human studies. The findings that have been discovered so far about this study chemical will be highlighted in this section.
But it’s important to realize that RAD-140 hasn’t received FDA clearance for usage in people. This substance is not meant for human consumption and should only be used in laboratory research.
Neuroprotection and RAD-140
In a study involving rats, scientists investigated the potential ability of RAD-140 to offer neuroprotection in cultured rat neurons and male rat brains. In cultured hippocampal neurons, RAD-140 was observed to be as effective as testosterone in reducing cell death induced by apoptotic insults.
In experiments with gonadectomized male rats, RAD-140 exhibited neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate, highlighting its preclinical efficiency in neuroprotective actions relevant to Alzheimer’s disease.
Mass of Muscle and RAD-140
One study investigated the anabolic effects of RAD-140 in young, male cynomolgus monkeys. Researchers examined gross body weight, which we know to be a sensitive marker of anabolic androgen action in young nonhuman primates.
While there was no consistent effect on absolute fat mass, the muscle mass showed a qualitative trend that increased with dosage. It appeared that the majority of muscle mass increase was due to lean mass increase. This shows the immense promise of potential muscular gains brought on by RAD-140.
In short, research suggests that RAD-140 may increase lean muscle. If the RAD 140 dosage is limited, however, these effects will be limited in subjects.
RAD-140 and Breast Cancer
RAD-140 is currently under investigation as a potential treatment for breast cancer.
In a cell study, oral administration of RAD-140 inhibited the growth of AR/ER+ breast cancer via the androgen receptor-mediated suppression of the ESR1 gene, both as a single agent and in combination with palbociclib (prescription medicine for certain types of breast cancer).
Androgen and estrogen-receptor-positive (AR/ER+) is a common form of breast cancer. It is sensitive to hormones, and therefore, medications that affect these receptors, such as SARMs like RAD 140, which are being investigated for their cancer-fighting potential.
How Does RAD-140 Work?
RAD-140 works by selectively targeting androgen receptors in the muscle and bone tissue, leading to a potential increase in lean muscle mass and a decrease in body fat.
This distinguishes RAD, as well as other SARMs, from anabolic steroids, testosterone, and DHT which do not spare androgen receptors in the reproductive organs.
Is RAD-140 Legal?
RAD-140 is legal to buy and sell as a research compound.
However, since this drug is on the World Anti-Doping Agency’s (WADA’s) list, it cannot be used by athletes and professionals. It is also illegal for human consumption.
What Is The Half-Life of RAD-140?
There are conflicting reports about the half-life of RAD 140. While some reports put the half-life at 16 hours, other researchers state that the compound has a long half-life of up to 60 hours.
Does RAD-140 Cause Testosterone Suppression?
According to a study conducted in 2010, 28 days of dosing with RAD 140 suppressed testosterone levels by approximately 200 – 300 ng/dL, with similar suppression in all three groups, although testosterone levels were significantly different for only the 0.01mg/kg group (p < 0.05).
Does RAD-140 Cause Acne in Subjects?
There is no mention of RAD 140 causing acne in this drug’s various animal studies.
Is RAD-140 Orally Bioavailable?
In pre-clinical characterization, this research compound had good bioavailability in rats and monkeys. Further research is needed to verify its bioavailability in humans.
RAD-140 has demonstrated anabolic activity on muscle in preclinical studies in rats and monkeys. In pre-clinical characterization, this research compound has demonstrated an excellent affinity for the androgen receptor. RAD also had good bioavailability in rats and monkeys.
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.
Product intended for research purposes
- The product (substance) isn’t a food or diet supplement and is unsuitable for human consumption.
- Keep out of children’s reach.
- Keep the container tightly closed.
- Store in a dry, cool and shaded place; protect from moisture.
- Store only in the original container.
- Avoid contact during pregnancy and breastfeeding.
- Consult a doctor if feeling unwell or having adverse effects related to contact with the substance.